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Article

Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation.

Molecular cell - 24 Oct 2013

Lu Yubing, Zhang Zhijun, Sun Danqiong, Sweeney Sean T, Gao Fen-Biao

Abstract excerpt

Phagophore maturation is a key step in the macroautophagy pathway, which is critical in many important physiological and pathological processes. Here we identified Drosophila N-ethylmaleimide-sensitive fusion protein 2 (dNSF2) and soluble NSF attachment protein (Snap) as strong genetic modifiers of mutant CHMP2B, an ESCRT-III component that causes frontotemporal dementia and autophagosome accumulation. Among...

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Identifiers

PMID: 24095276
DOI: 10.1016/j.molcel.2013.08.041
PMCID: PMC3825790

Genes

NSF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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