Article
A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation.
Science (New York, N.Y.) - 29 Jan 2016
Kaufman Charles K, Mosimann Christian, Fan Zi Peng, Yang Song, Thomas Andrew J, Ablain Julien, Tan Justin L, Fogley Rachel D, van Rooijen Ellen, Hagedorn Elliott J, Ciarlo Christie, White Richard M, Matos Dominick A, Puller Ann-Christin, Santoriello Cristina, Liao Eric C, Young Richard A, Zon Leonard I
Abstract excerpt
The "cancerized field" concept posits that cancer-prone cells in a given tissue share an oncogenic mutation, but only discreet clones within the field initiate tumors. Most benign nevi carry oncogenic BRAF(V600E) mutations but rarely become melanoma. The zebrafish crestin gene is expressed embryonically in neural crest progenitors (NCPs) and specifically reexpressed in melanoma. Live imaging of transgenic...
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