Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic studies of human-chimpanzee divergence using stem cell fusions.

Proceedings of the National Academy of Sciences of the United States of America - 21 Dec 2021

Song Janet H T, Grant Rachel L, Behrens Veronica C, Kučka Marek, Roberts Kingman Garrett A, Soltys Volker, Chan Yingguang Frank, Kingsley David M

Abstract excerpt

Complete genome sequencing has identified millions of DNA changes that differ between humans and chimpanzees. Although a subset of these changes likely underlies important phenotypic differences between humans and chimpanzees, it is currently difficult to distinguish causal from incidental changes and to map specific phenotypes to particular genome locations. To facilitate further genetic study of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Fusion
Share to Genome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomics

Share to Induced Pluripotent Stem Cells

Share to Pan troglodytes

Share to Ploidies

Share to Species Specificity

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 34921118
DOI: 10.1073/pnas.2117557118
PMCID: PMC8713981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic studies of human-chimpanzee divergence using stem cell fusions.PMID 34921118Read ↗

Genetic studies of human-chimpanzee divergence using stem cell fusionsSemantic proximity Read ↗

Generation of a Panel of Induced Pluripotent Stem Cells From Chimpanzees: a Resource for Comparative Functional GenomicsSemantic proximity Read ↗

Human-chimpanzee tetraploid system defines mechanisms of species-specific neural gene regulationSemantic proximity Read ↗

Primate cell fusion disentangles gene regulatory divergence in neurodevelopment.Semantic proximity Read ↗

A comparative study of endoderm differentiation in humans and chimpanzeesSemantic proximity Read ↗

Cell type-specific <i>cis</i> -regulatory divergence in gene expression and chromatin accessibility revealed by human-chimpanzee hybrid cellsSemantic proximity Read ↗

Mapping <i>cis</i> - and <i>trans</i> -regulatory target genes of human-specific deletionsSemantic proximity Read ↗

Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution.Semantic proximity Read ↗

Accounting for <i>cis</i> -regulatory constraint prioritizes genes likely to affect species-specific traitsSemantic proximity Read ↗

Retroviral insertions contributed to the divergence of human and chimpanzee brainsSemantic proximity Read ↗

Embryoid bodies facilitate comparative analysis of gene expression in humans and chimpanzees across dozens of cell typesSemantic proximity Read ↗

Evolutionary insights into primate skeletal gene regulation using a comparative cell culture modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.