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Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexes

12 Nov 2024

Abstract excerpt

Oncostatin M (OSM) is a unique Interleukin 6 (IL-6) family cytokine that plays pivotal roles in numerous biological events by signaling via two types of receptor complexes. While type I OSM receptor complex is formed by glycoprotein 130 (gp130) heterodimerization with Leukemia Inhibitory Factor receptor (LIFR), type II OSM receptor complex is composed of gp130 and OSM receptor (OSMR). OSM is an important...

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PMID: 39532904
DOI: 10.1038/s41467-024-54124-1

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