Article

Modeling pancreatic cancer tumor stroma co-evolution in an <i>in ovo</i> model

2026-06-27

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense, desmoplastic microenvironment that drives disease progression, yet conventional models fail to capture this complex tumor-stroma coevolution. Here, we utilize the chick chorioallantoic membrane (CAM) platform to investigate tumor-stroma interactions using murine PDAC cell lines and patient-derived organoids (PDOs). Integrating single-cell RNA seq...

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Literature Corpus work: 02044dea-9140-5754-b0d5-0783450f079b
DOI: 10.64898/2026.06.26.734719

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