Article

Mimicking tumor cell heterogeneity of colorectal cancer in a patient-derived organoid-fibroblast model

2022-03-08

Abstract excerpt

Patient-derived organoid (PDO) cancer models are generated from epithelial tumor cells. Although they reflect the molecular tumor characteristics, they lack the complexity of the tumor microenvironment, which is a key driver of tumorigenesis and therapy response. Here, we present a colorectal cancer (CRC) organoid model that incorporates epithelial cells and stromal fibroblasts from the same patient. Molecular cha...

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Literature Corpus work: 98dadc4c-0b8d-50fa-a960-d89ff39348df
DOI: 10.1101/2022.03.07.483214

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