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Article

Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia.

The Journal of biological chemistry - 8 Aug 2008

Doege Holger, Grimm Dirk, Falcon Alaric, Tsang Bernice, Storm Theresa A, Xu Hui, Ortegon Angelica M, Kazantzis Melissa, Kay Mark A, Stahl Andreas

Abstract excerpt

Non-alcoholic fatty liver disease is a serious health problem linked to obesity and type 2 diabetes. To investigate the biological outcome and therapeutic potential of hepatic fatty acid uptake inhibition, we utilized an adeno-associated virus-mediated RNA interference technique to knock down the expression of hepatic fatty acid transport protein 5 in vivo prior to or after establishing non-alcoholic fatty liver...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18524776
DOI: 10.1074/jbc.M803510200
PMCID: PMC2494916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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