Article
Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount.
eLife - 1 Jan 2014
Shi Mi, Yue Zhifeng, Kuryatov Alexandre, Lindstrom Jon M, Sehgal Amita
Abstract excerpt
In this study, we report a new protein involved in the homeostatic regulation of sleep in Drosophila. We conducted a forward genetic screen of chemically mutagenized flies to identify short-sleeping mutants and found one, redeye (rye) that shows a severe reduction of sleep length. Cloning of rye reveals that it encodes a nicotinic acetylcholine receptor α subunit required for Drosophila sleep. Levels of RYE...
Topics
- Animals
- Circadian Rhythm
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation
- Genotype
- Homeostasis
- Mutation
- Phenotype
- Photoperiod
- Receptors, Nicotinic