Article
Mettl5 coordinates protein production and degradation of PERIOD to regulate sleep in Drosophila.
eLife - 8 May 2026
Wu Xiaoyu, Yang Xingzhuo, Fu Tiantian, Rong Yikang, Du Juan
Abstract excerpt
Sleep plays a critical role in animal physiology, primarily governed by the brain, and its disruption is prevalent in various brain disorders. Mettl5 is associated with intellectual disability (ID), which often includes sleep disturbances. However, the mechanism underlying these sleep disruptions in ID remains poorly understood. In this study, we investigated the sleep phenotypes resulting from Drosophila Mettl5...
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