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Article

Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines

2021-10-31

Abstract excerpt

<h4>ABSTRACT</h4> Beta cells intrinsically contribute to the pathogenesis of type 1 diabetes (T1D), but the genes and molecular processes that mediate beta cell survival in T1D remain largely unknown. We combined high throughput functional genomics and human genetics to identify T1D risk loci regulating genes affecting beta cell survival in response to the proinflammatory cytokines IL-1β, IFNγ, and TNFα. We mappe...

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Literature Corpus work
0183df20-f848-53da-b97d-ac660dc10069
DOI
10.1101/2021.10.29.466025
Open publication

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Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokinesDOI 10.1101/2021.10.29.466025
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