Article

Meiosis-specific genes play roles in ploidy reduction in <i>Cryptococcus neoformans</i> titan cells

2025-09-18

Abstract excerpt

<h4>ABSTRACT</h4> Cryptococcus neoformans is a fungal pathogen of humans that causes life-threatening meningoencephalitis. During infection, enlarged, polyploid titan cells are produced that promote persistence in the host, in part by resisting phagocytosis; under stress conditions, such as exposure to the antifungal drug fluconazole, titan cells can produce aneuploid or diploid, drug-resistant daughter cells. Ho...

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Literature Corpus work: 016f926f-6d1e-54df-8609-3029e15db26e
DOI: 10.1101/2025.09.16.676405

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