Article
Parasexual Ploidy Reduction Drives Population Heterogeneity Through Random and Transient Aneuploidy in Candida albicans.
Genetics - 1 Jul 2015
Hickman Meleah A, Paulson Carsten, Dudley Aimee, Berman Judith
Abstract excerpt
The opportunistic pathogen Candida albicans has a large repertoire of mechanisms to generate genetic and phenotypic diversity despite the lack of meiosis in its life cycle. Its parasexual cycle enables shifts in ploidy, which in turn facilitate recombination, aneuploidy, and homozygosis of whole chromosomes to fuel rapid adaptation. Here we show that the tetraploid state potentiates ploidy variation and drives...
Topics
- Adaptation, Biological
- Aneuploidy
- Candida albicans
- Chromosomes, Fungal
- Genetic Variation
- Loss of Heterozygosity
- Tetraploidy