Polyploid Titan Cells Produce Haploid and Aneuploid Progeny To Promote Stress Adaptation

Abstract excerpt

UNLABELLED: Cryptococcus neoformans is a major life-threatening fungal pathogen. In response to the stress of the host environment, C. neoformans produces large polyploid titan cells. Titan cell production enhances the virulence of C. neoformans, yet whether the polyploid aspect of titan cells is specifically influential remains unknown. We show that titan cells were more likely to survive and produce offspring...

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