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Article

STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice

14 Oct 2016

Abstract excerpt

Objective Cytosolic DNA sensors detect microbial DNA and promote type I interferon (IFN) and proinflammatory cytokine production through the adaptor stimulator of IFN genes (STING) to resolve infection. Endogenous DNA also engages the STING pathway, contributing to autoimmune disease. This study sought to identify the role of STING in regulating bone formation and to define the bone phenotype and its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27740718
DOI: 10.1002/art.39863

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