Article

Cancer Immunotherapy Using AIRE Conditioning of the Tumor Epitopeome

2024-11-15

Abstract excerpt

<title>Abstract</title> <p>T cell immune tolerance is established in part through the activity of the Auto-immune Regulator (AIRE) transcription factor in the medullary Thymic Epithelial Cells (mTEC) of the thymus. AIRE induces expression of SELF peripheral tissue-specific antigens for presentation to naïve T cells to promote activation/deletion of potentially autoreactive T cells. We show, for the first time to...

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Literature Corpus work: 01692f34-b0ea-50bf-b8db-5ce0c08d21ac
DOI: 10.21203/rs.3.rs-5411393/v1

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