Article

Increased ‘selfness’ in the tumor emerges as a possible immune sculpting mechanism: A pan-cancer data analysis of 32 solid tumors in TCGA

2024-03-20

Abstract excerpt

Tumors pose a unique challenge to the immune system since they straddle the boundary between ‘self’ and ‘non-self’. T-cells recognize tumors that contain ‘non-self’ neo-antigens. They can also recognize tumors that contain aberrantly expressed self-antigens, highlighting the importance of the central tolerance and the tuning of the T-cell repertoire in the thymus. Therefore, the similarity to the thymic expression...

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Identifiers and source

Literature Corpus work: 7018c393-6ab0-50dd-b53a-7096e3f119b1
DOI: 10.1101/2024.03.18.585489

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