Article

Overcoming tolerance to tumour-antigens using molecularly informed epitope-modification to expand restructured oligoclonal CD4+ T-cell responses

2025-06-04

Abstract excerpt

<title>Abstract</title> Robust anti-tumour helper CD4+ T cell (TH1) responses can lead to control of cancers. However, the effectiveness of therapeutic vaccines to shared tumour associated antigens has often disappointed, reflecting a degree of immunological tolerance to germ-line encoded antigens. Bespoke modifications to HLA class II-presented epitopes, targeting the non-core bound pept...

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Literature Corpus work: 6df87288-527e-567c-b5e8-7f1605635b0c
DOI: 10.21203/rs.3.rs-6766731/v1

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