Article
Analysis of genetics and DNA methylation in osteoarthritis: What have we learnt about the disease?
Seminars in cell & developmental biology - 1 Feb 2017
Reynard Louise N
Abstract excerpt
Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is complex and highly heritable, with genetic variation estimated to contribute to 50% of OA occurrence. Epigenetic alterations, including DNA methylation changes, have also been implicated in OA pathophysiology. This review examines what...
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