Article
Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk.
Human molecular genetics - 20 Dec 2015
Rushton Michael D, Reynard Louise N, Young David A, Shepherd Colin, Aubourg Guillaume, Gee Fiona, Darlay Rebecca, Deehan David, Cordell Heather J, Loughlin John
Abstract excerpt
Osteoarthritis (OA) is a common, painful and debilitating disease of articulating joints resulting from the age-associated loss of cartilage. Well-powered genetic studies have identified a number of DNA polymorphisms that are associated with OA susceptibility. Like most complex trait loci, these OA loci are thought to influence disease susceptibility through the regulation of gene expression, so-called expression...
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