Article

Control iPSC lines with clinically annotated genetic variants for versatile multi-lineage differentiation

2019-06-10

Abstract excerpt

<h4>Summary</h4> Induced Pluripotent Stem Cells (iPSC) derived from healthy individuals are important controls for disease modeling studies. To create a resource of genetically annotated iPSCs, we reprogrammed footprint-free lines from four volunteers in the Personal Genome Project Canada (PGPC). Multilineage directed differentiation efficiently produced functional cortical neurons, cardiomyocytes and hepatocytes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e8749f9d-c48c-5c2f-b6a8-a433324ac302
DOI: 10.1101/666560

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Control iPSC lines with clinically annotated genetic variants for versatile multi-lineage differentiationDOI 10.1101/666560Read

Precision Health Resource of Control iPSC Lines for Versatile Multilineage Differentiation.Semantic proximity Read

A Library of Induced Pluripotent Stem Cells from Clinically Well-Characterized, Diverse Healthy Human IndividualsSemantic proximity Read

Editing stem cell genomes at scale to measure variant effects in diverse cell and genetic contextsSemantic proximity Read

A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals.Semantic proximity Read

Cytosine base editing workflow for quality-controlled multiplex-knockout hiPSC linesSemantic proximity Read

Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium AuthorsSemantic proximity Read

iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types.Semantic proximity Read

Humanity in a Dish: Population Genetics with iPSCs.Semantic proximity Read

Harnessing human genetics and stem cells for precision cardiovascular medicineSemantic proximity Read

Understanding the genetics behind complex human disease with large-scale iPSC collections.Semantic proximity Read

iSCORE-PD: an isogenic stem cell collection to research Parkinson's disease.Semantic proximity Read

Establishment and characterization of induced pluripotent stem cells from an individual with familial hypertrophic cardiomyopathy carrying the MYBPC3 c.772G>A mutationSemantic proximity Read