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A <i>Drosophila</i> Wolfram Syndrome 1 (WFS1) homologue synergises with the intracellular Ca <sup>2+</sup> release channel, IP <sub>3</sub> R to affect mitochondrial morphology and function

2022-11-12

Abstract excerpt

Wolfram syndrome (WFS) is an autosomal recessive neurodegenerative disorder, 90% of which is caused by loss of function of the endoplasmic reticular membrane protein Wolframin or WFS 1. Wolfram syndrome results in Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness (DIDMOAD) in humans. In mammalian cells WFS1 interacts with the ER-localised intracellular Ca 2+ release channel, Inositol Trisphosphat...

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Literature Corpus work
013c0d97-3793-5c91-ae03-1835d4f1dea5
DOI
10.1101/2022.11.10.515972
Open publication

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A <i>Drosophila</i> Wolfram Syndrome 1 (WFS1) homologue synergises with the intracellular Ca <sup>2+</sup> release channel, IP <sub>3</sub> R to affect mitochondrial morphology and functionDOI 10.1101/2022.11.10.515972
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