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Article

NCS1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of Wolfram syndrome

6 Oct 2022

Abstract excerpt

Wolfram syndrome (WS) is a rare neurodegenerative disease resulting in deafness, optic atrophy, diabetes, and neurological disorders. Currently, no treatment is available for patients. The mutated gene, WFS1 , encodes an endoplasmic reticulum (ER) protein, Wolframin. We previously reported that Wolframin regulated the ER-mitochondria Ca 2+ transfer and mitochondrial activity by protecting NCS1 from degradation in...

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PMID: 36320410
DOI: 10.1016/j.omtm.2022.10.003

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