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Synergism of IP3R and Parkin mutants identifies mitochondrial stress as an early feature of Parkinson's disease.

Disease models & mechanisms - 1 Jan 2026

Dileep Mrudula, Sharma Anamika, Kasturacharya Nandashree, Nizami Syed Kavish, Manjila Steffy, Bhan Ashita, Hasan Gaiti

Abstract excerpt

Our understanding of mechanisms underlying familial Parkinson's disease (PD) have benefitted from studies in Drosophila models of PD. However, in a majority of patients with PD, the disease occurs sporadically, and cellular phenotypes that arise early in sporadic PD are not yet fully understood. A genetic predisposition, arising from variants in pathways that impact dopaminergic neuron health could be one cause...

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Identifiers

PMID: 41235839
DOI: 10.1242/dmm.052146
PMCID: PMC12869514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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