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Article

Understanding the contrasting spatial haplotype patterns of malaria-protective β-globin polymorphisms.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Dec 2015

Hockham Carinna, Piel Frédéric B, Gupta Sunetra, Penman Bridget S

Abstract excerpt

The malaria-protective β-globin polymorphisms, sickle-cell (β(S)) and β(0)-thalassaemia, are canonical examples of human adaptation to infectious disease. Occurring on distinct genetic backgrounds, they vary markedly in their patterns of linked genetic variation at the population level, suggesting different evolutionary histories. β(S) is associated with five classical restriction fragment length polymorphism...

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Identifiers

PMID: 26394108
DOI: 10.1016/j.meegid.2015.09.018
PMCID: PMC4653953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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