Article

Whole genome sequence-based haplotypes reveal single origin of the sickle allele during the Holocene Wet Phase

2017-09-12

Abstract excerpt

<h4>ABSTRACT</h4> Five classical designations of sickle haplotypes are based on the presence/absence of restriction sites and named after ethnic groups or geographic regions from which patients originated. Each haplotype is thought to represent an independent occurrence of the sickle mutation. We investigated the origins of the sickle mutation using whole genome sequence data. We identified 156 carriers from the...

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Literature Corpus work: 7043ba74-8a7f-581c-9b69-217e6836ae85
DOI: 10.1101/187419

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