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Article

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.

Cell - 20 Jan 2012

Freed-Pastor William A, Mizuno Hideaki, Zhao Xi, Langerød Anita, Moon Sung-Hwan, Rodriguez-Barrueco Ruth, Barsotti Anthony, Chicas Agustin, Li Wencheng, Polotskaia Alla, Bissell Mina J, Osborne Timothy F, Tian Bin, Lowe Scott W, Silva Jose M, Børresen-Dale Anne-Lise, Levine Arnold J, Bargonetti Jill, Prives Carol

Abstract excerpt

p53 is a frequent target for mutation in human tumors, and mutant p53 proteins can actively contribute to tumorigenesis. We employed a three-dimensional culture model in which nonmalignant breast epithelial cells form spheroids reminiscent of acinar structures found in vivo, whereas breast cancer cells display highly disorganized morphology. We found that mutant p53 depletion is sufficient to phenotypically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Metabolic Networks and Pathways

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Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 22265415
DOI: 10.1016/j.cell.2011.12.017
PMCID: PMC3511889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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