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Article

Mutant p53 promotes cell spreading and migration via ARHGAP44.

Science China. Life sciences - 1 Sept 2017

Xu Jinjin, Jiao Jian, Xu Wei, Ji Lei, Jiang Dongjie, Xie Shaofang, Kubra Syeda, Li Xiaotao, Fu Junjiang, Xiao Jianru, Zhang Bianhong

Abstract excerpt

The tumor suppressor p53 protein is either lost or mutated in about half of all human cancers. Loss of p53 function is well known to influence cell spreading, migration and invasion. While expression of mutant p53 is not equivalent to p53 loss, mutant p53 can acquire new functions to drive cell spreading and migration via different mechanisms. In our study, we found that mutant p53 significantly increased cell...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to GTPase-Activating Proteins

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Share to Real-Time Polymerase Chain Reaction

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Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 28527113
DOI: 10.1007/s11427-016-9040-8

Genes

ARHGAP44

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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