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Article

Mechanical cues control mutant p53 stability through a mevalonate-RhoA axis.

Nature cell biology - 1 Jan 2018

Ingallina Eleonora, Sorrentino Giovanni, Bertolio Rebecca, Lisek Kamil, Zannini Alessandro, Azzolin Luca, Severino Luisa Ulloa, Scaini Denis, Mano Miguel, Mantovani Fiamma, Rosato Antonio, Bicciato Silvio, Piccolo Stefano, Del Sal Giannino

Abstract excerpt

Tumour-associated p53 missense mutants act as driver oncogenes affecting cancer progression, metastatic potential and drug resistance (gain-of-function) 1 . Mutant p53 protein stabilization is a prerequisite for gain-of-function manifestation; however, it does not represent an intrinsic property of p53 mutants, but rather requires secondary events 2 . Moreover, mutant p53 protein levels are often heterogeneous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29255172
DOI: 10.1038/s41556-017-0009-8
PMCID: PMC6179142

Genes

HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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