Article
Mutant p53 drives invasion by promoting integrin recycling.
Cell - 24 Dec 2009
Muller Patricia A J, Caswell Patrick T, Doyle Brendan, Iwanicki Marcin P, Tan Ee H, Karim Saadia, Lukashchuk Natalia, Gillespie David A, Ludwig Robert L, Gosselin Pauline, Cromer Anne, Brugge Joan S, Sansom Owen J, Norman Jim C, Vousden Karen H
Abstract excerpt
p53 is a tumor suppressor protein whose function is frequently lost in cancers through missense mutations within the Tp53 gene. This results in the expression of point-mutated p53 proteins that have both lost wild-type tumor suppressor activity and show gain of functions that contribute to transformation and metastasis. Here, we show that mutant p53 expression can promote invasion, loss of directionality of...
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