Article
Overexpression-based detection of translatable circular RNAs is vulnerable to coexistent linear RNA byproducts
2021-03-23
Abstract excerpt
In RNA field, the demarcation between coding and non-coding has been negotiated by the recent discovery of occasionally translated circular RNAs (circRNAs). Although absent of 5’ cap structure, circRNAs can be translated cap-independently. Complementary intron-mediated overexpression is one of the most utilized methodologies for circRNA research but not without bearing echoing skepticism for its poorly defined mec...
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Identifiers and source
- Literature Corpus work
- b7ebd2ab-1c1f-5f16-a653-61972a74294a
- DOI
- 10.1101/2021.03.23.433163