Article

ELOVL6 as a Therapeutic Target: Disrupting c-MYC-Driven Lipid Metabolism to Enhance Chemotherapy in Pancreatic Cancer

2024-11-11

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease, marked by a survival rate of only 12%. Consequently, the exploration of novel therapeutic strategies becomes a critical clinical imperative. Among the genetic alterations contributing to PDAC, c-MYC overexpression arises due to upstream mutations, amplifications, and copy number alterations. c-MYC serves as a key regulator in the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5407d4c5-c257-5fc5-86ad-146fdb0f4f81
DOI: 10.1101/2024.11.11.622928

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ELOVL6 as a Therapeutic Target: Disrupting c-MYC-Driven Lipid Metabolism to Enhance Chemotherapy in Pancreatic CancerDOI 10.1101/2024.11.11.622928Read

A comprehensive review of the family of very-long-chain fatty acid elongases: structure, function, and implications in physiology and pathologySemantic proximity Read

The Key Role of COA6 in Pancreatic Ductal Adenocarcinoma: Metabolic Reprogramming and Regulation of the Immune MicroenvironmentSemantic proximity Read

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancerSemantic proximity Read

Oncogenic KRAS triggers metabolic reprogramming in pancreatic ductal adenocarcinomaSemantic proximity Read

Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma.Semantic proximity Read

ELOVL6 activity attenuation induces mutant KRAS degradation.Semantic proximity Read

The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancerSemantic proximity Read

Targeting PIKfyve-driven lipid metabolism in pancreatic cancerSemantic proximity Read

Low expression of Elovl6 may involve in fat loss in white adipose tissue of cancer-associated cachexiaSemantic proximity Read

Crotonylation impedes c-Myc oncogenic activity.Semantic proximity Read

Lipid Metabolic Alterations in KRAS Mutant Tumors: Unmasking New Vulnerabilities for Cancer Therapy.Semantic proximity Read

SREBP-dependent regulation of lipid homeostasis is required for progression and growth of pancreatic ductal adenocarcinomaSemantic proximity Read