Article

Lung Adenocarcinoma Just Desserts: An Expanding Pie of Activating Oncogenes or a Layer Cake of Integrated Alterations

2025-09-21

Abstract excerpt

The molecular landscape of lung adenocarcinoma (LUAD) is often summarized as a “pie chart” of driver oncogenes, suggesting identification and targeting of oncogenic drivers is the best clinical approach. However, this model oversimplifies LUAD biology. Patients with identical RAS or RAF mutations exhibit heterogeneous signaling influenced by co-mutations, transcriptional programs, and lineage context. We propose a...

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Literature Corpus work: 819d9ee4-1db3-5b4a-9bf7-b64f92e4c60b
DOI: 10.1101/2025.09.19.677365

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