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Article

Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.

Cancer discovery - 1 Jun 2017

Jordan Emmet J, Kim Hyunjae R, Arcila Maria E, Barron David, Chakravarty Debyani, Gao JianJiong, Chang Matthew T, Ni Andy, Kundra Ritika, Jonsson Philip, Jayakumaran Gowtham, Gao Sizhi Paul, Johnsen Hannah C, Hanrahan Aphrothiti J, Zehir Ahmet, Rekhtman Natasha, Ginsberg Michelle S, Li Bob T, Yu Helena A, Paik Paul K, Drilon Alexander, Hellmann Matthew D, Reales Dalicia N, Benayed Ryma, Rusch Valerie W, Kris Mark G, Chaft Jamie E, Baselga José, Taylor Barry S, Schultz Nikolaus, Rudin Charles M, Hyman David M, Berger Michael F, Solit David B, Ladanyi Marc, Riely Gregory J

Abstract excerpt

Tumor genetic testing is standard of care for patients with advanced lung adenocarcinoma, but the fraction of patients who derive clinical benefit remains undefined. Here, we report the experience of 860 patients with metastatic lung adenocarcinoma analyzed prospectively for mutations in >300 cancer-associated genes. Potentially actionable genetic events were stratified into one of four levels based upon...

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Adenocarcinoma
Adenocarcinoma of Lung
Adolescent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Biomarkers, Tumor

Genetic Testing

Molecular Targeted Therapy

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Identifiers

PMID: 28336552
DOI: 10.1158/2159-8290.CD-16-1337
PMCID: PMC5482929

Genes

KEAP1
STK11

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