Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NLRP1 acts as a negative regulator of Th17 cell programming in mice and humans with autoimmune diabetes

1 May 2021

Abstract excerpt

Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of pancreatic β cells. We show here that the protein NOD-like receptor family pyrin domain containing 1 (NLRP1) has a key role in the pathogenesis of mouse and human T1D. More specifically, downregulation of NLRP1 expression occurs during T helper 17 (Th17) differentiation, alongside greater expression of several molecules related to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Diabetes Management and Research
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34038731
DOI: 10.1016/j.celrep.2021.109176

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NLRP1 acts as a negative regulator of Th17 cell programming in mice and humans with autoimmune diabetesPMID 34038731Read ↗

Downregulated NLRP3 and NLRP1 inflammasomes signaling pathways in the development and progression of type 1 diabetes mellitusSemantic proximity Read ↗

Cracking the type 1 diabetes code: Genes, microbes, immunity, and the early life environment.Semantic proximity Read ↗

Advances in our understanding of the pathophysiology of Type 1 diabetes: lessons from the NOD mouse.Semantic proximity Read ↗

Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and <i>β</i> ‐cell apoptosisSemantic proximity Read ↗

microRNAs in Type 1 Diabetes: Roles, Pathological Mechanisms, and Therapeutic PotentialSemantic proximity Read ↗

microRNAs in Type 1 Diabetes: Roles, Pathological Mechanisms, and Therapeutic PotentialSemantic proximity Read ↗

Inflammasomes and human autoimmunity: A comprehensive review.Semantic proximity Read ↗

Type 1 diabetes: lessons for other autoimmune diseases?Semantic proximity Read ↗

Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and functionSemantic proximity Read ↗

Targeting Innate Immunity for Type 1 Diabetes Prevention.Semantic proximity Read ↗

Dysfunction of regulatory T cells in pathogenesis of type 1 diabetes mellitusSemantic proximity Read ↗

Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onsetSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.