Article

Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium

2019-04-17

Abstract excerpt

Cigarette smoke first interacts with the lung through the cellularly diverse airway epithelium and goes on to drive development of most chronic lung diseases. Here, through single cell RNA-sequencing analysis of the tracheal epithelium from smokers and nonsmokers, we generated a comprehensive atlas of epithelial cell types and states, connected these into lineages, and defined cell-specific responses to smoking. O...

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Literature Corpus work: 69598300-050e-5dbd-91a7-3a39a80f9ef1
DOI: 10.1101/612747

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