Article

HGD-derived N-formylkynurenine promotes small cell lung cancer chemoresistance by activating ATL2-mediated endoplasmic reticulum remodelling.

2026-01-22

Abstract excerpt

<title>Abstract</title> Tumour cells often express molecules that drive aberrant metabolism and exhibit distinct metabolic patterns to adapt to chemotherapeutic stress, leading to therapeutic resistance. Here, we report that homogentisate 1,2-dioxygenase (HGD) drives the accumulation of N-formylkynurenine (FK) to promote chemotherapy resistance in small cell lung cancer (SCLC) cells. Transcriptomic and metabol...

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Literature Corpus work: ab3b2f88-bfe6-5ef6-b219-28f67d34e54a
DOI: 10.21203/rs.3.rs-8510398/v1

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HGD-derived N-formylkynurenine promotes small cell lung cancer chemoresistance by activating ATL2-mediated endoplasmic reticulum remodelling.DOI 10.21203/rs.3.rs-8510398/v1Read

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