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Lactate dehydrogenase B noncanonically promotes ferroptosis defense in KRAS-driven lung cancer

6 Dec 2024

Abstract excerpt

Ferroptosis is an oxidative, non-apoptotic cell death frequently inactivated in cancer, but the underlying mechanisms in oncogene-specific tumors remain poorly understood. Here, we discover that lactate dehydrogenase (LDH) B, but not the closely related LDHA, subunits of active LDH with a known function in glycolysis, noncanonically promotes ferroptosis defense in KRAS-driven lung cancer. Using murine models and...

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PMID: 39643712
DOI: 10.1038/s41418-024-01427-x

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