Article

Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

2020-07-11

Abstract excerpt

Bi-allelic loss of TP53 and RB1 in treatment-naïve small cell lung cancer (SCLC) suggests strong selective pressure to inactivate regulated cell death pathways prior to therapy. Yet, which regulated cell death pathways remain available in treatment-naïve SCLC is unknown. Here, through systemic analysis of cell death pathway availability, we identify non-neuroendocrine (NE) and NE SCLC subtypes to segregate by th...

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Literature Corpus work: ece5b8f7-853e-55c2-97b4-984d8092faea
DOI: 10.1101/2020.07.11.198408

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