Impact of CCR5Δ32 on the risk of infection, Staphylococcus aureus carriage, and plasma concentrations of chemokines in Danish blood donors.

doi:10.1016/j.ebiom.2024.105406

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Article

Impact of CCR5Δ32 on the risk of infection, Staphylococcus aureus carriage, and plasma concentrations of chemokines in Danish blood donors.

EBioMedicine - 1 Nov 2024

Dinh Khoa Manh, Kaspersen Kathrine Agergård, Mikkelsen Susan, Kjerulff Bertram Dalskov, Boldsen Jens Kjærgaard, Petersen Mikkel Steen, Burgdorf Kristoffer Sølvsten, Sørensen Erik, Aagaard Bitten, Forman-Ankjær Barbara, Bruun Mie Topholm, Banasik Karina, Hansen Thomas Folkmann, Nyegaard Mette, Rohde Palle Duun, Brunak Søren, Hjalgrim Henrik, Ostrowski Sisse Rye, Pedersen Ole Birger, Ullum Henrik, Erikstrup Lise Tornvig, Erikstrup Christian

Abstract excerpt

BACKGROUND: The CC chemokine receptor 5 (CCR5) is a suggested receptor for Staphylococcus aureus leukotoxin ED. Homozygosity for the Δ32 deletion (CCR5Δ32) protects against human immunodeficiency virus infection and possibly also against leukotoxin ED. We examined the impact of CCR5Δ32 on the susceptibility to S. aureus infection, all-cause infections, and S. aureus nasal carriage, respectively, and on the...

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Identifiers

PMID: 39437658
DOI: 10.1016/j.ebiom.2024.105406
PMCID: PMC11536029

Genes

CCL4
CCL11
CCL2
CCR5
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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