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Article

Restriction enzyme selection dictates detection range sensitivity in chromatin conformation capture-based variant-to-gene mapping approaches.

Human genetics - 1 Oct 2021

Su Chun, Pahl Matthew C, Grant Struan F A, Wells Andrew D

Abstract excerpt

Promoter-focused chromatin conformation techniques directly detect interactions between gene promoters and distal genomic sequences, providing structural information relevant to gene regulation without the excessive non-genic architectural data generated by full-scale Hi-C. 3D promoter 'interactome' maps are crucial for understanding how epigenomic features such as histone modifications and open chromatin, or...

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Identifiers

PMID: 34405268
DOI: 10.1007/s00439-021-02326-8
PMCID: PMC9013487

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