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Article

Biocompatible polymeric nanocomplexes as an intracellular stimuli-sensitive prodrug for type-2 diabetes combination therapy.

Biomaterials - 1 Dec 2015

Wang Feng-Zhen, Xie Zhi-Shen, Xing Lei, Zhang Bing-Feng, Zhang Jia-Liang, Cui Peng-Fei, Qiao Jian-Bin, Shi Kun, Cho Chong-Su, Cho Myung-Haing, Xu Xiaojun, Li Ping, Jiang Hu-Lin

Abstract excerpt

Combination therapy is usually considered as a promising strategy owing to its advantages such as reduced doses, minimized side effects and improved therapeutic efficiency in a variety of diseases including diabetes. Here we synthesized a new highly intracellular stimuli-sensitive chitosan-graft-metformin (CS-MET) prodrug by imine reaction between oxidative chitosan and metformin for type 2 diabetes (T2D)...

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PMID: 26409000
DOI: 10.1016/j.biomaterials.2015.09.013

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MET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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