Article

Exploring Mechanisms of Lipid Nanoparticle-Mucus Interactions in Healthy and Cystic Fibrosis Conditions

2024-01-22

Abstract excerpt

<h4>ABSTRACT</h4> Mucus forms the first defense line of human lungs, and as such hampers the efficient delivery of therapeutics to the underlying epithelium. This holds particularly true for genetic cargo such as CRISPR-based gene editing tools which cannot readily surmount the mucosal barrier. While lipid nanoparticles (LNPs) emerged as versatile non-viral gene delivery systems that could help overcome the deliv...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 12be6a3e-67ec-5092-8c79-f8c578db26ca
DOI: 10.1101/2024.01.18.575680

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exploring Mechanisms of Lipid Nanoparticle-Mucus Interactions in Healthy and Cystic Fibrosis ConditionsDOI 10.1101/2024.01.18.575680Read

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site-Specific Integration of CFTR and Mutation-Agnostic Disease RescueSemantic proximity Read

A combinatorial biomolecular strategy to identify peptides for improved transport across the sputum of cystic fibrosis patients and the underlying epitheliaSemantic proximity Read

Oral Spatiotemporal Nanoassembly for Sequential Genetic Reprogramming from Gut to Periphery OrganSemantic proximity Read

Inhaled gene therapy of preclinical muco-obstructive lung diseases by nanoparticles capable of breaching the airway mucus barrierSemantic proximity Read

Assisting PNA Transport Through Cystic Fibrosis Human Airway Epithelia With Biodegradable Hybrid Lipid-Polymer NanoparticlesSemantic proximity Read

Impact of Formulation Conditions on Lipid Nanoparticle Characteristics and Functional Delivery of CRISPR RNP for Gene Knock-Out and CorrectionSemantic proximity Read

Lipid Nanoparticles for In Vivo Lung Delivery of CRISPR-Cas9 Ribonucleoproteins Allow Gene Editing of Clinical TargetsSemantic proximity Read

Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imagingSemantic proximity Read

A General High-throughput Mucus Microrheology Platform For Personalized MedicineSemantic proximity Read

Optimizations of In Vitro Mucus and Cell Culture Models to Better Predict In Vivo Gene Transfer in Pathological Lung Respiratory Airways: Cystic Fibrosis as an ExampleSemantic proximity Read

Lung surfactants as a component of lipid nanoparticles for pulmonary mRNA deliverySemantic proximity Read

Efficient Cas9 nuclease-based editing in skeletal muscle via lipid nanoparticle deliverySemantic proximity Read