Article

IN VIVO ANALYSIS OF THE ROLE OF GASDERMIN-B (GSDMB) IN CANCER USING NOVEL KNOCK-IN MOUSE MODELS

2021-05-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Gasdermin-B gene (GSDMB) is frequently over-expressed in tumors, and its shortest translated variant (isoform 2; GSDMB2) increases aggressive behavior in breast cancer cells. Paradoxically, GSDMB could have either pro-tumor or tumor suppressor properties depending on the biological context. Since GSDMB gene is not present in the mouse genome, deciphering fully the functional...

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Literature Corpus work: 0070ee41-2a34-55b9-9b72-944906a28054
DOI: 10.1101/2021.05.27.445936

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