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Article

Insights from transgenic mouse models of ERBB2-induced breast cancer.

Nature reviews. Cancer - 1 May 2007

Ursini-Siegel Josie, Schade Babette, Cardiff Robert D, Muller William J

Abstract excerpt

One-third of patients with breast cancer overexpress the ERBB2 receptor tyrosine kinase, which is associated not only with a more aggressive phenotype but also reduced responsiveness to hormonal therapies. Over the past two decades, many ERBB2 mouse models for breast cancer have conclusively shown that this receptor has a causal role in breast cancer development. These mouse models have also enabled the...

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Source

Identifiers

PMID: 17446858
DOI: 10.1038/nrc2127

Genes

ERBB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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