Article

A Syngeneic Immunocompetent Mouse Model of Gallbladder Cancer Reveals Tumorigenesis and Therapeutic Response

2025-11-18

Abstract excerpt

<h4>Purpose</h4> Gallbladder cancer (GBC) is a rare but highly lethal malignancy with one of the poorest prognoses among cancers of the digestive system cancers. However, current experimental models of GBC face critical limitations, particularly their dependence on immunodeficient hosts, which precludes the investigation of the tumor microenvironment. We aimed to establish a novel syngeneic immunocompetent mouse...

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Literature Corpus work: d0d211eb-44cc-567a-b9a3-39ac1feab839
DOI: 10.1101/2025.11.17.687512

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