Back to search

Article

A susceptibility gene signature for ERBB2-driven mammary tumor development and metastasis in Collaborative Cross mice with human translational value

2024-01-09

Abstract excerpt

<h4>Background</h4> Deeper insights into ERBB2-driven cancers are essential to develop novel treatment avenues for ERBB2+ breast cancers (BCs). We employed Collaborative Cross (CC) mouse model, along with human translational evaluation, to unearth genetic factors underpinning Erbb2-driven mammary tumor development and metastasis. <h4>Methods</h4> 732 F1 hybrid female mice between FVB/N MMTV- Erbb2 and 30 CC strain...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
986c4b85-4aea-5a64-8ff5-4210cb62ab43
DOI
10.1101/2024.01.08.24300993
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A susceptibility gene signature for ERBB2-driven mammary tumor development and metastasis in Collaborative Cross mice with human translational valueDOI 10.1101/2024.01.08.24300993
A susceptibility gene signature for ERBB2-driven mammary tumour development and metastasis in collaborative cross mice.Semantic proximity
Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterpartsSemantic proximity
Determining susceptibility loci in triple negative breast cancer using a novel pre-clinical modelSemantic proximity
Integrative multi-omic sequencing reveals the MMTV-Myc mouse model mimics human breast cancer heterogeneitySemantic proximity
Cross-Species and Tissue-Agnostic Prediction of Human Cancer Treatment Response using AI-Powered Cellular Morphometric Biomarkers from a Genetically Diverse Erbb2 Mouse ModelSemantic proximity
A Novel Mouse Model that Recapitulates the Heterogeneity of Human Triple Negative Breast CancerSemantic proximity
Integrative multi-omic sequencing reveals the MMTV-Myc mouse model mimics human breast cancer heterogeneity.Semantic proximity
Investigating the genomic landscape of mouse models of breast cancer metastasisSemantic proximity
A Lung Cancer Mouse Model DatabaseSemantic proximity
Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer.Semantic proximity
The Mouse Models of Human Cancer database (MMHCdb).Semantic proximity
Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification.Semantic proximity
Select a neighboring publication to make it the new centre.