Article

Human genetic analyses of organelles highlight the nucleus in age-related trait heritability

2021-01-22

Abstract excerpt

Most age-related human diseases are accompanied by a decline in cellular organelle integrity, including impaired lysosomal proteostasis and defective mitochondrial oxidative phosphorylation. An open question, however, is the degree to which inherited variation in or near genes encoding each organelle contributes to age-related disease pathogenesis. Here, we evaluate if genetic loci encoding organelle proteomes con...

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Literature Corpus work: 006f2fe4-b70f-571c-ae67-d70acf4b2e28
DOI: 10.1101/2021.01.22.427431

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