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Article

Human genetic analyses of organelles highlight the nucleus in age-related trait heritability.

eLife - 1 Sept 2021

Gupta Rahul, Karczewski Konrad J, Howrigan Daniel, Neale Benjamin M, Mootha Vamsi K

Abstract excerpt

Most age-related human diseases are accompanied by a decline in cellular organelle integrity, including impaired lysosomal proteostasis and defective mitochondrial oxidative phosphorylation. An open question, however, is the degree to which inherited variation in or near genes encoding each organelle contributes to age-related disease pathogenesis. Here, we evaluate if genetic loci encoding organelle proteomes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34467851
DOI: 10.7554/eLife.68610
PMCID: PMC8476128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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