Article
Germline burden of rare damaging variants negatively affects human healthspan and lifespan
2019-10-13
Abstract excerpt
Genome-wide association studies often explore links between particular genes and phenotypes of interest. Known genetic variants, however, are responsible for only a small fraction of human lifespan variation evident from genetic twin studies. To account for the missing longevity variance, we hypothesized that the cumulative effect of deleterious variants may affect human longevity. Here, we report that the burden...
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Identifiers and source
- Literature Corpus work
- c9156595-592d-5916-a53a-eb66675d5f39
- DOI
- 10.1101/802082