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High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity

10 Aug 2022

Abstract excerpt

Mitochondrial dysfunction is a well-known contributor to aging and age-related diseases. The precise mechanisms through which mitochondria impact human lifespan, however, remain unclear. We hypothesize that humans with exceptional longevity harbor rare variants in nuclear-encoded mitochondrial genes (mitonuclear genes) that confer resistance against age-related mitochondrial dysfunction. Here we report an...

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PMID: 35948858
DOI: 10.1007/s11357-022-00634-z

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